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Article

Brain beta-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1.

Neurochemical research - 1 Dec 2004

Turner Bradley J, Li Qiao-Xin, Laughton Katrina M, Masters Colin L, Lopes Elizabeth C, Atkin Julie D, Cheema Surindar S

Abstract excerpt

Oxidative stress is implicated in both the deposition and pathogenesis of beta-amyloid (Abeta) protein in Alzheimer's disease (AD). Accordingly, overexpression of the antioxidant enzyme superoxide dismutase 1 (SOD1) in neuronal cells and transgenic AD mice reduces Abeta toxicity and accumulation. In contrast, mutations in SOD1 associated with amyotrophic lateral sclerosis (ALS) confer enhanced pro-oxidative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15672551
DOI: 10.1007/s11064-004-7037-z

Genes

SOD1
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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