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Article

Sodium channel mutations and susceptibility to heart failure and atrial fibrillation.

JAMA - 26 Jan 2005

Olson Timothy M, Michels Virginia V, Ballew Jeffrey D, Reyna Sandra P, Karst Margaret L, Herron Kathleen J, Horton Steven C, Rodeheffer Richard J, Anderson Jeffrey L

Abstract excerpt

CONTEXT: Dilated cardiomyopathy (DCM), a genetically heterogeneous disorder, causes heart failure and rhythm disturbances. The majority of identified DCM genes encode structural proteins of the contractile apparatus and cytoskeleton. Recently, genetic defects in calcium and potassium regulation have been discovered in patients with DCM, implicating an alternative disease mechanism. The full spectrum of genetic...

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Identifiers

PMID: 15671429
DOI: 10.1001/jama.293.4.447
PMCID: PMC2039897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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