Article
Localization of a critical interface for helical rod formation of bacterial adhesion P-pili.
Journal of molecular biology - 11 Feb 2005
Mu Xiang-Qi, Jiang Zhenghui G, Bullitt Esther
Abstract excerpt
Pyelonephritic Escherichia coli cause urinary tract infections that involve the kidneys. Initiation of infection is dependent on P-pili expressed on the bacterial surface. In this work, an essential interface for assembly of the helical rod structure of P-pili has been located on the major pilin subunit, PapA. Based on primary sequence alignment, secondary structure analysis, and quaternary structure modeling of...
Topics
- Bacterial Adhesion
- Binding Sites
- Escherichia coli
- Escherichia coli Proteins
- Fimbriae Proteins
- Fimbriae, Bacterial
- Microscopy, Electron
- Models, Molecular
- Mutation
- Protein Structure, Tertiary
