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Article

A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis.

The EMBO journal - 9 Feb 2005

Terada Kazutoyo, Yomogida Kentaro, Imai Tomoaki, Kiyonari Hiroshi, Takeda Naoki, Kadomatsu Tsuyoshi, Yano Masato, Aizawa Shinichi, Mori Masataka

Abstract excerpt

Two type I DnaJ homologs DjA1 (DNAJA1; dj2, HSDJ/hdj-2, rdj1) and DjA2 (DNAJA2; dj3, rdj2) work similarly as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. To study the in vivo role of DjA1, we generated DjA1-mutant mice. Surprisingly, loss of DjA1 in mice led to severe defects in spermatogenesis that involve aberrant androgen signaling. Transplantation experiments with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Androgen

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Source

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Identifiers

PMID: 15660130
DOI: 10.1038/sj.emboj.7600549
PMCID: PMC548655

Genes

DNAJA1
DNAJA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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