Article
Downregulation of Newcastle disease virus (NDV)-dependent IFN-alpha/beta production in macrophages by IFN-induced gene products of the locus If-1.
Research in immunology - 1 Jan 1992
Zawatzky R, Wurmbaeck H
Abstract excerpt
We have found that in cultured mouse bone-marrow-derived macrophages (BMDM), endogenous IFN-beta specifically regulates Newcastle disease virus (NDV) induced interferon (IFN)-alpha/beta synthesis, possibly by influencing the activity of genes within the regulatory locus If-1. Comparison of anti-IFN-beta-treated BMDM from C57BL/6 mice and the congenic line B.6C-H28c carrying the high (h) or low (l) producer allele...
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