Article
Blockade of the Fas/FasL system improves pneumococcal clearance from the lungs without preventing dissemination of bacteria to the spleen.
The Journal of infectious diseases - 15 Feb 2005
Matute-Bello Gustavo, Liles W Conrad, Frevert Charles W, Dhanireddy Shireesha, Ballman Kimberly, Wong Venus, Green Richard R, Song Ho Yeong, Witcher Derrick R, Jakubowski Joseph A, Martin Thomas R
Abstract excerpt
BACKGROUND: The Fas/FasL system is both proapoptotic and proinflammatory. FasL is inhibited by decoy receptor-3 (DcR3), a naturally occurring decoy receptor. We determined the effects of systemic blockade of the Fas/FasL system by a DcR3 analog (DcR3-a) in mice with pneumococcal pneumonia. METHODS: Streptococcus pneumoniae (7.2 x 105 or 1.9 x 107 cfu/mL) was instilled intratracheally into untreated C57Bl/6 mice,...
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