A Distinct “Side Population” of Cells in Human Tumor Cells: Implications for Tumor Biology and Therapy

Abstract excerpt

Since the early genetic studies in yeast, regulation of the cell cycle has been associated with the sequential activation of several proline-directed serine-threonine protein kinases by cyclins. From yeast to humans, the activity of these cyclin-dependent kinases (Cdks) have been thought to be essential for cell cycle regulation. Recent gene-targeted mouse models for different cyclins and Cdks have shown that...

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