Article
Obtaining comparative genomic data with the VISTA family of computational tools.
Current protocols in bioinformatics - 1 Jun 2009
Ratnere Igor, Dubchak Inna
Abstract excerpt
Comparison of DNA sequences from different species is a fundamental method for identifying functional elements, such as exons or enhancers, as they tend to exhibit significant sequence similarity due to purifying selection. Availability of whole-genome sequences for a constantly growing number of organisms makes identification of such elements within these genomes possible. There are two distinct phases in...
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