Article
Repair of the tRNA-like CCA sequence in a multipartite positive-strand RNA virus.
Journal of virology - 1 Feb 2005
Hema M, Gopinath K, Kao C
Abstract excerpt
The 3' portions of plus-strand brome mosaic virus (BMV) RNAs mimic cellular tRNAs. Nucleotide substitutions or deletions in the 3'CCA of the tRNA-like sequence (TLS) affect minus-strand initiation unless repaired. We observed that 2-nucleotide deletions involving the CCA 3' sequence in one or all BMV RNAs still allowed RNA accumulation in barley protoplasts at significant levels. Alterations of CCA to GGA in only...
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