Repair of the tRNA-like CCA sequence in a multipartite positive-strand RNA virus.

doi:10.1128/JVI.79.3.1417-1427.2005

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Article

Repair of the tRNA-like CCA sequence in a multipartite positive-strand RNA virus.

Journal of virology - 1 Feb 2005

Hema M, Gopinath K, Kao C

Abstract excerpt

The 3' portions of plus-strand brome mosaic virus (BMV) RNAs mimic cellular tRNAs. Nucleotide substitutions or deletions in the 3'CCA of the tRNA-like sequence (TLS) affect minus-strand initiation unless repaired. We observed that 2-nucleotide deletions involving the CCA 3' sequence in one or all BMV RNAs still allowed RNA accumulation in barley protoplasts at significant levels. Alterations of CCA to GGA in only...

Topics

Base Sequence
Bromovirus
Hordeum
Molecular Sequence Data
Mutation
Protoplasts
RNA, Transfer
RNA, Viral
Sequence Deletion

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Identifiers

PMID: 15650168
DOI: 10.1128/JVI.79.3.1417-1427.2005
PMCID: PMC544147

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