Article
Naturally occurring mutations in replication proteins of a small RNA virus that alter the number, sizes, and relative abundances of subgenomic RNAs.
PLoS pathogens - 1 Jul 2026
Perdoncini Carvalho Camila, Wang Deya, Han Junping, Khemsom Khwannarin, Chen Hanqiao, Tao Yizhi, Qu Feng
Abstract excerpt
Many positive-strand (+) RNA viruses produce subgenomic RNAs (sgRNAs) in infected cells. sgRNAs are synthesized by virus-encoded replication proteins (RPs), but whether RPs regulate the number and sizes of sgRNAs remains largely unknown. We report multiple naturally occurring mutations within the RPs of turnip crinkle virus (TCV) that alter the number, sizes, and relative abundances of TCV sgRNAs. TCV is a (+)...
Topics
- Subgenomic RNA
- Mutation
- Viral Proteins
- RNA, Viral
- Virus Replication
- Carmovirus
- RNA Replication
- Nicotiana
- Genome, Viral