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Article

A mutation in the enamelin gene in a mouse model.

Journal of dental research - 1 Aug 2007

Seedorf H, Klaften M, Eke F, Fuchs H, Seedorf U, Hrabe de Angelis M

Abstract excerpt

Amelogenesis imperfecta is an inherited disorder affecting tooth enamel formation. We previously isolated a mouse strain with an amelogenesis imperfecta phenotype (ATE1 mice) from a dominant ethylnitrosourea screen and mapped the disease-causing defect to a 9-cM region of mouse chromosome 5. In the current study, we tested the hypothesis that there is a mutation in enamelin (ENAM) or ameloblastin (AMBN), both of...

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Source

Identifiers

PMID: 17652207
DOI: 10.1177/154405910708600815

Genes

ATE1
AMBN
ENAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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