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Article

Prion protein with Y145STOP mutation induces mitochondria-mediated apoptosis and PrP-containing deposits in vitro.

Biochemical and biophysical research communications - 18 Feb 2005

Hachiya Naomi S, Watanabe Kota, Kawabata Makiko Y, Jozuka Akiko, Kozuka Yoshimichi, Sakasegawa Yuji, Kaneko Kiyotoshi

Abstract excerpt

A pathogenic truncation of an amber mutation at codon 145 (Y145STOP) in Gerstmann-Straussler-Scheinker disease (GSS) was investigated through the real-time imaging in living cells, by utilizing GFP-PrP constructs. GFP-PrP(1-144) exhibited an aberrant localization to mitochondria in mouse neuroblastoma neuro2a (N2a) and HpL3-4 cells, a hippocampal cell line established from prnp gene-ablated mice, whereas...

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Source

Identifiers

PMID: 15649429
DOI: 10.1016/j.bbrc.2004.12.079

Genes

GSS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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