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The host exosome pathway underpins biogenesis of the human cytomegalovirus virion

10 Sept 2020

Abstract excerpt

Human Cytomegalovirus (HCMV) infects over half the world's population, is a leading cause of congenital birth defects, and poses serious risks for immuno-compromised individuals. To expand the molecular knowledge governing virion maturation, we analysed HCMV virions using proteomics, and identified a significant proportion of host exosome constituents. To validate this acquisition, we characterized exosomes...

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PMID: 32910773
DOI: 10.7554/elife.58288

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