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Article

Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors.

The Journal of experimental medicine - 17 Jan 2005

Fiebiger Edda, Tortorella Domenico, Jouvin Marie-Helene, Kinet Jean-Pierre, Ploegh Hidde L

Abstract excerpt

The human high affinity receptor for IgE (FcepsilonRI) is a cell surface structure critical for the pathology of allergic reactions. Human FcepsilonRI is expressed as a tetramer (alphabetagamma(2)) on basophils or mast cells and as trimeric (alphagamma(2)) complex on antigen-presenting cells. Expression of the human alpha subunit can be down-regulated by a splice variant of FcepsilonRIbeta (beta(var)). We...

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Identifiers

PMID: 15642744
DOI: 10.1084/jem.20041384
PMCID: PMC2212795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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