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Article

Prenylation inhibitors stimulate both estrogen receptor alpha transcriptional activity through AF-1 and AF-2 and estrogen receptor beta transcriptional activity.

Breast cancer research : BCR - 1 Jan 2005

Cestac Philippe, Sarrabayrouse Guillaume, Médale-Giamarchi Claire, Rochaix Philippe, Balaguer Patrick, Favre Gilles, Faye Jean-Charles, Doisneau-Sixou Sophie

Abstract excerpt

INTRODUCTION: We showed in a previous study that prenylated proteins play a role in estradiol stimulation of proliferation. However, these proteins antagonize the ability of estrogen receptor (ER) alpha to stimulate estrogen response element (ERE)-dependent transcriptional activity, potentially through the formation of a co-regulator complex. The present study investigates, in further detail, how prenylated...

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Identifiers

PMID: 15642170
DOI: 10.1186/bcr956
PMCID: PMC1064103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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