Point mutations in the major outer membrane protein drive hypervirulence of a rapidly expanding clone of <i>Campylobacter jejuni</i>

Abstract excerpt

Infections due to clonal expansion of highly virulent bacterial strains are clear and present threats to human and animal health. Association of genetic changes with disease is now a routine, but identification of causative mutations that enable disease remains difficult. Campylobacter jejuni is an important zoonotic pathogen transmitted to humans mainly via the foodborne route. C. jejuni typically colonizes the...

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