Article
Molecular and clinical aspects of inherited cardiomyopathies.
Annals of medicine - 1 Jun 1995
Durand J B, Abchee A B, Roberts R
Abstract excerpt
Hypertrophic cardiomyopathy (HCM) is phenotypically and genotypically a heterogeneous disease. Since 1989, four chromosomal loci have been identified for HCM and the genes residing on three of these have been identified as beta-myosin heavy chain (beta-MHC), cardiac troponin-T and alpha-tropomyosin. These genes code for sarcomeric proteins and exhibit the same phenotype, suggesting that HCM is a disease of the...
Topics
- Cardiomyopathy, Dilated
- Cardiomyopathy, Hypertrophic
- Chromosome Mapping
- Genotype
- Humans
- Muscle Proteins
- Myosin Heavy Chains
- Phenotype
- Point Mutation
- Prognosis