Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Up-regulation of 94-kDa glucose-regulated protein by hypoxia-inducible factor-1 in human endothelial cells in response to hypoxia.

FEBS letters - 3 Jan 2005

Paris Sébastien, Denis Hélène, Delaive Edouard, Dieu Marc, Dumont Valéry, Ninane Noëlle, Raes Martine, Michiels Carine

Abstract excerpt

Hypoxic environment in solid tumor is known to favor cell survival and to initiate the formation of new capillaries. In this work, we identified by 2D gel analysis 94-kDa glucose-regulated protein (GRP94) as being upregulated in human endothelial cells in response to hypoxia. Three putative hypoxia responsive elements (HRE) were found in the GRP94 promoter. Competition experiments of HIF-1 DNA binding using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Extracts
Share to Cell Hypoxia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to HSP70 Heat-Shock Proteins

Share to Hypoxia-Inducible Factor 1

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Luciferases

Share to Response Elements

Source

Identifiers

PMID: 15620698
DOI: 10.1016/j.febslet.2004.11.055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Up-regulation of 94-kDa glucose-regulated protein by hypoxia-inducible factor-1 in human endothelial cells in response to hypoxia.PMID 15620698Read ↗

Egr-1 target genes in human endothelial cells identified by microarray analysisSemantic proximity Read ↗

Hypoxia Modulates HLA-G Gene Expression in Tumor CellsSemantic proximity Read ↗

Differential Gene Up-Regulation by Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α in HEK293T CellsSemantic proximity Read ↗

Induction of glucose transporter 1 expression through hypoxia-inducible factor 1α under hypoxic conditions in trophoblast-derived cellsSemantic proximity Read ↗

The angiopoietin‐2 gene of endothelial cells is up‐regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA‐2 and Ets‐1Semantic proximity Read ↗

Structural Characterization of the Interaction of Hypoxia Inducible Factor-1 with Its Hypoxia Responsive Element at the -964G > A Variation Site of the HLA-G Promoter Region.Semantic proximity Read ↗

Candidate genes for the hypoxic tumor phenotype.Semantic proximity Read ↗

Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1.Semantic proximity Read ↗

Hypoxia induces PTHrP gene transcription in human cancer cells through the HIF-2αSemantic proximity Read ↗

Identification of hypoxia-response element in the human endothelial nitric-oxide synthase gene promoter.Semantic proximity Read ↗

Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer.Semantic proximity Read ↗

Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.