Article
The evolution of signaling complexity suggests a mechanism for reducing the genomic search space in human association studies.
Molecular psychiatry - 1 Jan 2005
Irizarry K J L, Merriman B, Bahamonde M E, Wong M-L, Licinio J
Abstract excerpt
The size complexity of the human genome has been traditionally viewed as an obstacle that frustrates efforts aimed at identifying the genetic correlates of complex human phenotypes. As such complex phenotypes are attributed to the combined action of numerous genomic loci, attempts to identify the underlying multi-locus interactions may produce a combinatorial sum of false positives that drown out the real signal....
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