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Article

Endometrial cancer is a receptor-mediated target for Mullerian Inhibiting Substance

23 Dec 2004

Abstract excerpt

Mullerian Inhibiting Substance (MIS), a 140-kDa homodimer glycoprotein member of the TGF-beta superfamily of biological-response modifiers, causes regression of the Mullerian ducts in developing male embryos. MIS also can induce growth arrest and apoptosis in ovarian and cervical cancer cell lines. The embryonic progenitor of the ovarian and cervical epithelium is the coelomic epithelium, the same tissue that...

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PMID: 15618407
DOI: 10.1073/pnas.0407772101

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