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Article

Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation.

Genes & development - 15 Oct 1996

Mishina Y, Rey R, Finegold M J, Matzuk M M, Josso N, Cate R L, Behringer R R

Abstract excerpt

Müllerian-inhibiting substance (MIS) is a member of the transforming growth factor-beta (TGF-beta) gene family. MIS expression in males causes the regression of the Müllerian ducts, an essential process in male sexual differentiation. Recently, an MIS type II receptor gene has been isolated that is expressed during embryogenesis in mesenchymal cells adjacent to the Müllerian duct epithelium and in Sertoli and...

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Identifiers

PMID: 8895659
DOI: 10.1101/gad.10.20.2577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation.PMID 8895659Read ↗

The müllerian inhibitor and mammalian sexual development.Semantic proximity Read ↗

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Mullerian Inhibiting Substance Signaling Uses a Bone Morphogenetic Protein (BMP)-Like Pathway Mediated by ALK2 and Induces Smad6 ExpressionSemantic proximity Read ↗

Genetic studies of the AMH/MIS signaling pathway for Müllerian duct regression.Semantic proximity Read ↗

A single base pair mutation encoding a premature stop codon in the MIS type II receptor is responsible for canine persistent Müllerian duct syndrome.Semantic proximity Read ↗

New insights into mullerian inhibiting substance and its mechanism of actionSemantic proximity Read ↗

Requirement of Bmpr1a for Müllerian duct regression during male sexual development.Semantic proximity Read ↗

Endometrial cancer is a receptor-mediated target for Mullerian Inhibiting SubstanceSemantic proximity Read ↗

Molecular Genetics of Müllerian Duct Formation, Regression and DifferentiationSemantic proximity Read ↗

Mullerian inhibiting substance: an update.Semantic proximity Read ↗

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