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Article

Müllerian Inhibiting Substance Inhibits Ovarian Cell Growth through an Rb-independent Mechanism

1 Nov 2000

Abstract excerpt

Müllerian inhibiting substance (MIS), a transforming growth factor-beta family member, causes regression of the Müllerian duct in male embryos. MIS overexpression in transgenic mice ablates the ovary, and MIS inhibits the growth of ovarian cancer cell lines in vitro, suggesting a key role for this hormone in postnatal development of the ovary. This report describes a mechanism for MIS-mediated growth inhibition...

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PMID: 10958795
DOI: 10.1074/jbc.m005701200

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