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Article

A single base pair mutation encoding a premature stop codon in the MIS type II receptor is responsible for canine persistent Müllerian duct syndrome.

Journal of andrology - 1 Jan 2000

Wu Xiufeng, Wan Shengqin, Pujar Shashikant, Haskins Mark E, Schlafer Donald H, Lee Mary M, Meyers-Wallen Vicki N

Abstract excerpt

Müllerian inhibiting substance (MIS), a secreted glycoprotein in the transforming growth factor-beta family of growth factors, mediates regression of the Müllerian ducts during embryonic sex differentiation in males. In persistent Müllerian duct syndrome (PMDS), rather than undergoing involution, the Müllerian ducts persist in males, giving rise to the uterus, fallopian tubes, and upper vagina. Genetic defects in...

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Identifiers

PMID: 18723470
DOI: 10.2164/jandrol.108.005736
PMCID: PMC2593750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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