Article
Association of peripheral and central arterial wave reflections with the CYP11B2 -344C allele and sodium excretion.
Journal of hypertension - 1 Dec 2004
Wojciechowska Wiktoria, Staessen Jan A, Stolarz Katarzyna, Nawrot Tim, Filipovský Jan, Tichá Milena, Bianchi Giuseppe, Brand Eva, Cwynar Marcin, Grodzicki Tomasz, Kuznetsova Tatiana, Struijker-Boudier Harry A, Svobodová Vlasta, Thijs Lutgarde, Van Bortel Luc M, Kawecka-Jaszcz Kalina
Abstract excerpt
OBJECTIVE: Angiotensin II and aldosterone, generated by the angiotensin-converting enzyme (ACE) and aldosterone synthase (CYP11B2), respectively, not only regulate sodium and water homeostasis, but also influence vascular remodeling in response to high blood pressure. In the European Project on Genes in Hypertension (EPOGH), we therefore investigated whether the ACE I/D and CYP11B2 C-344T polymorphisms influence...
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