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Article

Preferential association of aldosterone synthase gene polymorphism with central blood pressure and wave reflections in hypertensive individuals.

Journal of human hypertension - 1 Apr 2010

Blacher J, Kakou A, Lacombe J-M, Safar M E

Abstract excerpt

In hypertensive humans, the CC genotype of the aldosterone synthase gene polymorphism (ASGP) CYP11B(2) (C-344T variant) is associated with increased aortic stiffness. Whether ASGP is also associated with altered central (carotid) wave reflections has never been investigated. After 1-month wash-out period, 124 hypertensive individuals were submitted to measurements of brachial and carotid systolic blood pressure...

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Source

Identifiers

PMID: 19609286
DOI: 10.1038/jhh.2009.59

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