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Article

Epstein-barr virus-infected resting memory B cells, not proliferating lymphoblasts, accumulate in the peripheral blood of immunosuppressed patients.

The Journal of experimental medicine - 16 Aug 1999

Babcock G J, Decker L L, Freeman R B, Thorley-Lawson D A

Abstract excerpt

When Epstein-Barr virus (EBV) infects B cells in vitro, the result is a proliferating lymphoblast that expresses at least nine latent proteins. It is generally believed that these cells are rigorously controlled in vivo by cytotoxic T cells. Consistent with this, the latently infected cells in the peripheral blood of healthy carriers are not lymphoblasts. Rather, they are resting memory B cells that are probably...

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Identifiers

PMID: 10449527
DOI: 10.1084/jem.190.4.567
PMCID: PMC2195601

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