Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intergenotypic chimeric hepatitis E viruses (HEVs) with the genotype 4 human HEV capsid gene in the backbone of genotype 3 swine HEV are infectious in pigs.

Virus research - 1 Mar 2011

Feagins Alicia R, Córdoba Laura, Sanford Brent J, Dryman Barbara A, Huang Yao-Wei, LeRoith Tanya, Emerson Suzanne U, Meng Xiang-Jin

Abstract excerpt

Genotypes 1 and 2 hepatitis E virus (HEV) infect only humans whereas genotypes 3 and 4 HEV infect both humans and pigs. To evaluate the mechanism of cross-species HEV infection between humans and swine, in this study we constructed five intergenotypic chimeric viruses and tested for their infectivity in vitro and in pigs. We demonstrated that chimeric viruses containing the ORF2 capsid gene either alone or in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capsid Proteins
Share to Gene Order

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hep G2 Cells

Share to Hepatitis E

Share to Hepatitis E virus

Share to Swine Diseases

Share to Viremia

Share to Virus Shedding

Source

Open in PubMed Open full text

Identifiers

PMID: 21195119
DOI: 10.1016/j.virusres.2010.12.011
PMCID: PMC3045649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intergenotypic chimeric hepatitis E viruses (HEVs) with the genotype 4 human HEV capsid gene in the backbone of genotype 3 swine HEV are infectious in pigs.PMID 21195119Read ↗

Rescue of a genotype 4 human hepatitis E virus from cloned cDNA and characterization of intergenotypic chimeric viruses in cultured human liver cells and in pigs.Semantic proximity Read ↗

A novel virus in swine is closely related to the human hepatitis E virusSemantic proximity Read ↗

Swine hepatitis E virus: Cross-species infection, pork safety and chronic infection.Semantic proximity Read ↗

Cross-species infection of specific-pathogen-free pigs by a genotype 4 strain of human hepatitis E virus.Semantic proximity Read ↗

A novel subgenotype 3a hepatitis E virus isolated from pigs in China.Semantic proximity Read ↗

Assessment of the cross-protective capability of recombinant capsid proteins derived from pig, rat, and avian hepatitis E viruses (HEV) against challenge with a genotype 3 HEV in pigs.Semantic proximity Read ↗

Genetic and experimental evidence for cross-species infection by swine hepatitis E virus.Semantic proximity Read ↗

Capped RNA Transcripts of Full-Length cDNA Clones of Swine Hepatitis E Virus Are Replication Competent When Transfected into Huh7 Cells and Infectious When Intrahepatically Inoculated into PigsSemantic proximity Read ↗

Prior infection of pigs with a genotype 3 swine hepatitis E virus (HEV) protects against subsequent challenges with homologous and heterologous genotypes 3 and 4 human HEV.Semantic proximity Read ↗

Full-length genome of a novel genotype 3 hepatitis E virus strain obtained from domestic pigs in Japan.Semantic proximity Read ↗

Comparison of Hepatitis E Virus Sequences from Humans and Swine, the Netherlands, 1998-2015.Semantic proximity Read ↗

Identity of a Novel Swine Hepatitis E Virus in Taiwan Forming a Monophyletic Group with Taiwan Isolates of Human Hepatitis E VirusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.