Article
Oligogenic combinations associated with breast cancer risk in women under 53 years of age.
Human genetics - 1 Feb 2005
Aston Christopher E, Ralph David A, Lalo Dominique P, Manjeshwar Sharmila, Gramling Bobby A, DeFreese Daniele C, West Amy D, Branam Dannielle E, Thompson Linda F, Craft Melissa A, Mitchell Debra S, Shimasaki Craig D, Mulvihill John J, Jupe Eldon R
Abstract excerpt
Common, but weakly penetrant, functional polymorphisms probably account for most of the genetic risk for breast cancer in the general population. Current polygenic risk models assume that component genes act independently. To test for potential gene-gene interactions, single nucleotide polymorphisms in ten genes with known or predicted roles in breast carcinogenesis were examined in a case-control study of 631...
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