Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Embryonic stem cells differentiate into insulin-producing cells without selection of nestin-expressing cells.

The International journal of developmental biology - 1 Dec 2004

Blyszczuk Przemyslaw, Asbrand Christian, Rozzo Aldo, Kania Gabriela, St-Onge Luc, Rupnik Marjan, Wobus Anna M

Abstract excerpt

We present a new strategy for the differentiation of embryonic stem (ES) cells into insulin-producing cells via a multi-step process without selection and induction of nestin-positive cells. During ES cell differentiation, transcript levels of genes characteristic of early and mature beta cells including Pdx1, Pax4, insulin and islet amyloid pancreatic peptide are up regulated. Islet-like clusters are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to C-Peptide
Share to Cell Culture Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophysiology

Share to Intermediate Filament Proteins

Share to Islets of Langerhans

Share to Keratins

Share to Nestin

Share to Streptozocin

Source

Identifiers

PMID: 15602695
DOI: 10.1387/ijdb.041904pb

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Embryonic stem cells differentiate into insulin-producing cells without selection of nestin-expressing cells.PMID 15602695Read ↗

Insulin-producing cells.Semantic proximity Read ↗

Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes.Semantic proximity Read ↗

Insulin-Producing Cells Derived from Human Embryonic Stem Cells: Comparison of Definitive Endoderm- and Nestin-Positive Progenitor-Based Differentiation StrategiesSemantic proximity Read ↗

Generation of Insulin-Producing Islet-Like Clusters from Human Embryonic Stem CellsSemantic proximity Read ↗

Differentiation of mouse embryonic stem cells into pancreatic and hepatic cells.Semantic proximity Read ↗

Regulated Expression of pdx-1 Promotes In Vitro Differentiation of Insulin-Producing Cells From Embryonic Stem CellsSemantic proximity Read ↗

[Pancreatic stem cells--a new therapeutic option for the treatment of type 1 diabetes mellitus?].Semantic proximity Read ↗

Generation of insulin‐secreting cells from human embryonic stem cellsSemantic proximity Read ↗

Three-Dimensional Differentiation of Embryonic Stem Cells into Islet-like Insulin-Producing ClustersSemantic proximity Read ↗

Directed Differentiation of Human Embryonic Stem Cells into the Pancreatic Endocrine LineageSemantic proximity Read ↗

An INSULIN and IAPP dual reporter enables tracking of functional maturation of stem cell-derived insulin producing cellsSemantic proximity Read ↗

Adult pancreas generates multipotent stem cells and pancreatic and nonpancreatic progeny.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.