Article
Linkage disequilibrium analysis of case-control data: an application to generalized aggressive periodontitis.
Genes and immunity - 1 Feb 2005
Scapoli C, Trombelli L, Mamolini E, Collins A
Abstract excerpt
Several studies have shown a role for the involvement of interleukin (IL)-1 gene cluster polymorphisms in the risk of periodontal diseases. In the present study, we tested polymorphisms, derived from genes of the IL-1 cluster, for association with generalized aggressive periodontitis (GAP) through both allelic association and by constructing a linkage disequilibrium (LD) map of the 2q13-14 disease candidate...
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