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Article

Genetic power of a Brazilian three-generation family with generalized aggressive periodontitis.

Brazilian dental journal - 1 Jan 2010

Rapp Gisela Estela, Pineda-Trujillo Nicolas, McQuillin Andrew, Tonetti Maurizio

Abstract excerpt

Aggressive periodontitis is a multifactorial disease with strong familial aggregation. Genetic linkage analysis is a method to localize causative or predisposing genes along the chromosome, thus helping to unravel important pathogenic pathways. Prior to applying this method, however, it is essential to estimate the power of the study design. The aim of this study was to estimate the power of a large Brazilian...

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Identifiers

PMID: 20640360
DOI: 10.1590/s0103-64402010000200008

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