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Ler Is a Negative Autoregulator of the<i>LEE1</i>Operon in Enteropathogenic<i>Escherichia coli</i>

15 Dec 2004

Abstract excerpt

Enteropathogenic Escherichia coli (EPEC) causes severe diarrhea in young children. Essential for colonization of the host intestine is the LEE pathogenicity island, which comprises a cluster of operons encoding a type III secretion system and related proteins. The LEE1 operon encodes Ler, which positively regulates many EPEC virulence genes in the LEE region and elsewhere in the chromosome. We found that Ler acts...

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PMID: 15601719
DOI: 10.1128/jb.187.1.349-357.2005

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Related research

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Research trail→

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Ler Is a Negative Autoregulator of the<i>LEE1</i>Operon in Enteropathogenic<i>Escherichia coli</i>PMID 15601719Read ↗

Activation of enteropathogenic <i>Escherichia coli</i> (EPEC) <i>LEE2</i> and <i>LEE3</i> operons by LerSemantic proximity Read ↗

Mutational analysis of the locus of enterocyte effacement-encoded regulator (Ler) of enteropathogenic Escherichia coli.Semantic proximity Read ↗

The Per regulon of enteropathogenic <i>Escherichia coli</i> : identification of a regulatory cascade and a novel transcriptional activator, the locus of enterocyte effacement (LEE)‐encoded regulator (Ler)Semantic proximity Read ↗

The Locus of Enterocyte Effacement (LEE)-Encoded Regulator Controls Expression of Both LEE- and Non-LEE-Encoded Virulence Factors in Enteropathogenic and Enterohemorrhagic <i>Escherichia coli</i>Semantic proximity Read ↗

Identification of a negative regulator for the pathogenicity island of enterohemorrhagic Escherichia coli O157:H7.Semantic proximity Read ↗

A Positive Regulatory Loop Controls Expression of the Locus of Enterocyte Effacement-Encoded Regulators Ler and GrlASemantic proximity Read ↗

Locus of Enterocyte Effacement: A Pathogenicity Island Involved in the Virulence of Enteropathogenic and Enterohemorragic<i>Escherichia coli</i>Subjected to a Complex Network of Gene RegulationSemantic proximity Read ↗

Global Regulation by Horizontally Transferred Regulators Establishes the Pathogenicity of Escherichia coliSemantic proximity Read ↗

Environment Controls LEE Regulation in Enteropathogenic Escherichia coliSemantic proximity Read ↗

Control freaks—signals and cues governing the regulation of virulence in attaching and effacing pathogensSemantic proximity Read ↗

Concert of regulators to switch on LEE expression in enterohemorrhagic Escherichia coli O157:H7: Interplay between Ler, GrlA, HNS and RpoSSemantic proximity Read ↗

Interaction of Ler at the LEE5 ( tir ) Operon of Enteropathogenic Escherichia coliSemantic proximity Read ↗

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