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Article

Effects of topoisomerase 2 inhibitors on the MLL gene in children receiving chemotherapy: a prospective study.

Leukemia - 1 Feb 2005

Ng A, Taylor G M, Wynn R F, Eden O B

Abstract excerpt

The molecular effects of etoposide in haemopoietic cells suggest that mixed lineage leukaemia (MLL) abnormalities can be biomarkers of patient susceptibility to the genotoxic effects of topoisomerase 2 (topo 2) inhibitors. We have prospectively studied treatment-related MLL cleavage and rearrangement in serial samples from 71 children receiving chemotherapy, using Southern blot analysis and panhandle PCR. The...

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Identifiers

PMID: 15592432
DOI: 10.1038/sj.leu.2403599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effects of topoisomerase 2 inhibitors on the MLL gene in children receiving chemotherapy: a prospective study.PMID 15592432Read ↗

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DNA Cleavage within the<i>MLL</i>Breakpoint Cluster Region Is a Specific Event Which Occurs as Part of Higher-Order Chromatin Fragmentation during the Initial Stages of ApoptosisSemantic proximity Read ↗

The Efficacy of Topoisomerase II-Targeted Anticancer Agents Reflects the Persistence of Drug-Induced Cleavage Complexes in CellsSemantic proximity Read ↗

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