Article
A molecular epidemiologic study of thalassemia using newborns' cord blood in a multiracial Asian population in Singapore: results and recommendations for a population screening program.
Journal of pediatric hematology/oncology - 1 Dec 2004
Kham S K, Yin Shirley Kham Kow, Quah Thuan Chong, Loong Ai Mei, Tan Poh Lin, Fraser Angus, Chong S S, Chuan Samuel Chong Siong, Yeoh A E, Eng-Juh Allen Yeoh
Abstract excerpt
DNA technology provides a new avenue to perform neonatal screening tests for single-gene diseases in populations of high frequency. Thalassemia is one of the high-frequency single-gene disorders affecting Singapore and many countries in the malaria belt. The authors explored the feasibility of using PCR-based diagnostic screening on 1,116 unselected sequential cord blood samples for neonatal screening. The cord...
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