Article
Analysis of a variable number tandem repeat polymorphism in the huntingtin interacting protein-1 related gene for anticipation in bipolar affective disorder.
Progress in neuro-psychopharmacology & biological psychiatry - 1 Dec 2004
Provençal Nadine, Shink Eric, Harvey Mario, Tremblay Monique, Barden Nicholas
Abstract excerpt
The anticipation phenomenon, described as either an increase in disease severity, a decrease in age at onset, or both, in successive generations, has been suggested as a possibility of genetic transmission for bipolar affective disorder. We report here investigation of the stability of intergenerational transmission of a variable number tandem repeat (VNTR) polymorphism, found in the Huntingtin interacting...
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