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Article

Induction and reversal of cardiac phenotype of human hypertrophic cardiomyopathy mutation cardiac troponin T-Q92 in switch on-switch off bigenic mice.

Journal of the American College of Cardiology - 7 Dec 2004

Lutucuta Silvia, Tsybouleva Natalia, Ishiyama Masukuni, Defreitas Gilberto, Wei Lei, Carabello Blase, Marian A J

Abstract excerpt

OBJECTIVES: The aim of this study was to establish reversibility of cardiac phenotypes in hypertrophic cardiomyopathy (HCM) by generating bigenic mice in which expression of the mutant transgene could be turned on and off as needed. BACKGROUND: Advances in molecular therapeutics could ultimately lead to therapies aimed at correcting the causal mutations. However, whether cardiac phenotypes, once established, are...

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Source

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Identifiers

PMID: 15582321
DOI: 10.1016/j.jacc.2004.09.005
PMCID: PMC2774751

Genes

NPPA
NPPB
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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