Article
Low-calcemic, efficacious, 1alpha,25-dihydroxyvitamin D3 analog QW-1624F2-2: calcemic dose-response determination, preclinical genotoxicity testing, and revision of A-ring stereochemistry.
Steroids - 1 Jan 2000
Posner Gary H, Jeon Heung Bae, Sarjeant Amy, Riccio Edward S, Doppalapudi Rupa S, Kapetanovic Izet M, Saha Uttam, Dolan Patrick, Kensler Thomas W
Abstract excerpt
Based on an X-ray crystal structure determination, the A-ring stereochemistry of hybrid analog QW-1624F2-2 (1alpha-hydroxymethyl-16-ene-24,24-difluoro-25-hydroxy-26,27-bis-homovitamin D3) is revised to be 1alpha-CH2OH-3beta-OH. This analog is shown to be approximately 80-100 times less calciuric than the natural hormone 1alpha,25-dihydoxyvitamin D3. This analog is shown also to be non-genotoxic in three different...
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