Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

22-Alkyl-20-epi-1alpha,25-dihydroxyvitamin D3 compounds of superagonistic activity: syntheses, biological activities and interaction with the receptor.

Journal of medicinal chemistry - 8 Mar 2007

Yamamoto Keiko, Inaba Yuka, Yoshimoto Nobuko, Choi Mihwa, DeLuca Hector F, Yamada Sachiko

Abstract excerpt

We previously reported that 22R-methyl-20-epi-1,25-(OH)2D3 (3) possesses strong binding affinity for the vitamin D receptor (VDR) and shows superagonistic biological activities. To examine the effect of the length of an alkyl substituent at C(22) and to extend our compound library, we successfull...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Calcitriol
Share to HL-60 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Vitro Techniques

Share to Intestinal Mucosa

Share to Radioligand Assay

Share to Receptors, Calcitriol

Share to Stereoisomerism

Source

Identifiers

PMID: 17298045
DOI: 10.1021/jm060889f

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17298045-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

22-Alkyl-20-epi-1alpha,25-dihydroxyvitamin D3 compounds of superagonistic activity: syntheses, biological activities and interaction with the receptor.PMID 17298045Read ↗

1α,25(OH)2-3-Epi-Vitamin D3, a Natural Physiological Metabolite of Vitamin D3: Its Synthesis, Biological Activity and Crystal Structure with Its ReceptorSemantic proximity Read ↗

Structural refinement of seco-steroidal skeleton and the biological activity through nuclear receptors.Semantic proximity Read ↗

Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands.Semantic proximity Read ↗

The pleiotropic actions of vitamin DSemantic proximity Read ↗

Convergent synthesis and biological evaluation of vitamin D analogues as potential anticancer agentsSemantic proximity Read ↗

The vitamin D receptor as a therapeutic targetSemantic proximity Read ↗

Vitamin D and cancer: an update of in vitro and in vivo dataSemantic proximity Read ↗

Differential gene regulation by a synthetic vitamin D receptor ligand and active vitamin D in human cellsSemantic proximity Read ↗

The importance of the putative helices 4 and 5 of human vitamin D(3) receptor for conformation and ligand binding.Semantic proximity Read ↗

A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.Semantic proximity Read ↗

Rational design of vitamin D3 analogues which selectively restore activity to a vitamin D receptor mutant associated with rickets.Semantic proximity Read ↗

On the mechanism underlying (23S)-25-dehydro-1alpha(OH)-vitamin D3-26,23-lactone antagonism of hVDRwt gene activation and its switch to a superagonist.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.