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Article

The crucial role of Campylobacter jejuni genes in anti-ganglioside antibody induction in Guillain-Barre syndrome.

The Journal of clinical investigation - 1 Dec 2004

Godschalk Peggy C R, Heikema Astrid P, Gilbert Michel, Komagamine Tomoko, Ang C Wim, Glerum Jobine, Brochu Denis, Li Jianjun, Yuki Nobuhiro, Jacobs Bart C, van Belkum Alex, Endtz Hubert P

Abstract excerpt

Molecular mimicry of Campylobacter jejuni lipo-oligosaccharides (LOS) with gangliosides in nervous tissue is considered to induce cross-reactive antibodies that lead to Guillain-Barre syndrome (GBS), an acute polyneuropathy. To determine whether specific bacterial genes are crucial for the biosynthesis of ganglioside-like structures and the induction of anti-ganglioside antibodies, we characterized the C. jejuni...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15578098
DOI: 10.1172/JCI15707
PMCID: PMC529276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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