Article
Methylenetetrahydrofolate reductase gene A222V polymorphism and risk of ischemic stroke.
Clinical chemistry and laboratory medicine - 1 Jan 2004
Baum Larry, Wong Ka Sing, Ng Ho Keung, Tomlinson Brian, Rainer Timothy Hudson, Chan Daniel Kam Yin, Thomas G Neil, Chen Xiangyan, Poon Peter, Cheung Wing Sze, Woo Kam Sang
Abstract excerpt
The 5,10-methylenetetrahydrofolate reductase ( MTHFR ) gene 677C --> T polymorphism causes an A222V amino acid change which affects MTHFR enzyme activity and can increase homocysteine, a vascular disease risk factor. This polymorphism was examined for association with stroke. In a case-control study of 241 ischemic stroke patients and 304 controls in Hong Kong, the V allele increased in stroke [28% vs. 20%, odds...
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