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Article

Reconstructing large regions of an ancestral mammalian genome in silico.

Genome research - 1 Dec 2004

Blanchette Mathieu, Green Eric D, Miller Webb, Haussler David

Abstract excerpt

It is believed that most modern mammalian lineages arose from a series of rapid speciation events near the Cretaceous-Tertiary boundary. It is shown that such a phylogeny makes the common ancestral genome sequence an ideal target for reconstruction. Simulations suggest that with methods currently available, we can expect to get 98% of the bases correct in reconstructing megabase-scale euchromatic regions of an...

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PMID: 15574820
DOI: 10.1101/gr.2800104
PMCID: PMC534665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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