Article
The Met-196 -> Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-alpha-induced apoptosis by impaired NF-kappaB signaling and target gene expression.
The Journal of biological chemistry - 18 Feb 2005
Till Andreas, Rosenstiel Philip, Krippner-Heidenreich Anja, Mascheretti-Croucher Silvia, Croucher Peter J P, Schäfer Heiner, Scheurich Peter, Seegert Dirk, Schreiber Stefan
Abstract excerpt
Tumor necrosis factor-alpha (TNF-alpha)-induced signaling is pivotally involved in the pathogenesis of chronic inflammatory diseases. A polymorphism in the TNF receptor 2 (TNFR2) gene resulting in a juxtamembrane inversion from methionine (TNFR2(196MET)) to arginine (TNFR2(196ARG)) has been genetically associated with an increased risk for systemic lupus erythematosus and familial rheumatoid arthritis. Albeit the...
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