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Detection of Methylated Apoptosis-Associated Genes in Urine Sediments of Bladder Cancer Patients

15 Nov 2004

Abstract excerpt

PURPOSE: There is increasing evidence for a fundamental role for epigenetic silencing of apoptotic pathways in cancer. Changes in DNA methylation can be detected with a high degree of sensitivity, so we used the MethyLight assay to determine how methylation patterns of apoptosis-associated genes change during bladder carcinogenesis and whether DNA methylation could be detected in urine sediments. EXPERIMENTAL...

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PMID: 15569975
DOI: 10.1158/1078-0432.ccr-04-0930

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