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Article

Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction.

Circulation - 14 Dec 2004

Ming Xiu-Fen, Barandier Christine, Viswambharan Hema, Kwak Brenda R, Mach François, Mazzolai Lucia, Hayoz Daniel, Ruffieux Jean, Rusconi Sandro, Montani Jean-Pierre, Yang Zhihong

Abstract excerpt

BACKGROUND: Arginase competes with endothelial nitric oxide synthase (eNOS) for the substrate l-arginine and decreases NO production. This study investigated regulatory mechanisms of arginase activity in endothelial cells and its role in atherosclerosis. METHODS AND RESULTS: In human endothelial...

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Source

Identifiers

PMID: 15569838
DOI: 10.1161/01.CIR.0000142867.26182.32

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15569838-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction.PMID 15569838Read ↗

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