Article
Structural insights into FtsZ protofilament formation.
Nature structural & molecular biology - 1 Dec 2004
Oliva Maria A, Cordell Suzanne C, Löwe Jan
Abstract excerpt
The prokaryotic tubulin homolog FtsZ polymerizes into a ring structure essential for bacterial cell division. We have used refolded FtsZ to crystallize a tubulin-like protofilament. The N- and C-terminal domains of two consecutive subunits in the filament assemble to form the GTPase site, with the C-terminal domain providing water-polarizing residues. A domain-swapped structure of FtsZ and biochemical data on...
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