Article
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma.
American journal of respiratory and critical care medicine - 15 Mar 2005
Choudhry Shweta, Ung Ngim, Avila Pedro C, Ziv Elad, Nazario Sylvette, Casal Jesus, Torres Alfonso, Gorman Jennifer D, Salari Keyan, Rodriguez-Santana Jose R, Toscano Monica, Sylvia Jody Senter, Alioto MariaElena, Castro Richard A, Salazar Michael, Gomez Ivan, Fagan Joanne K, Salas Jorge, Clark Suzanne, Lilly Craig, Matallana Henry, Selman Moises, Chapela Rocio, Sheppard Dean, Weiss Scott T, Ford Jean G, Boushey Homer A, Drazen Jeffrey M, Rodriguez-Cintron William, Silverman Edwin K, Burchard Esteban González
Abstract excerpt
BACKGROUND: In the United States, Puerto Ricans and Mexicans have the highest and lowest asthma prevalence, morbidity, and mortality, respectively. Ethnic-specific differences in the response to drug treatment may contribute to differences in disease outcomes. Genetic variants at the beta(2)-adrenergic receptor (beta(2)AR) may modify asthma severity and albuterol responsiveness. We tested the association of...
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