Article
Sp3 is involved in the regulation of SOCS3 gene expression.
The Biochemical journal - 1 May 2005
Ehlting Christian, Häussinger Dieter, Bode Johannes G
Abstract excerpt
Cytokine-induced expression of SOCS (suppressor of cytokine signalling) molecules is important for the negative regulatory control of STAT (signal transduction and activators of transcription)-dependent cytokine signalling, e.g. for the signal transduction of IL-6 (interleukin-6)-type cytokines through the JAK (Janus kinase)/STAT cascade. STAT activation itself represents an important step in the transcriptional...
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