Article
Significant contribution of germline BRCA2 rearrangements in male breast cancer families.
Cancer research - 15 Nov 2004
Tournier Isabelle, Paillerets Brigitte Bressac-de, Sobol Hagay, Stoppa-Lyonnet Dominique, Lidereau Rosette, Barrois Michel, Mazoyer Sylvie, Coulet Florence, Hardouin Agnès, Chompret Agnès, Lortholary Alain, Chappuis Pierre, Bourdon Violaine, Bonadona Valérie, Maugard Christine, Gilbert Brigitte, Nogues Catherine, Frébourg Thierry, Tosi Mario
Abstract excerpt
Although screening for large deletions or duplications of the BRCA1 gene is becoming a routine component of the molecular diagnosis of familial breast cancer, little is known about the occurrence of such rearrangements in the BRCA2 gene. Because of the high frequency of BRCA2 mutations in breast cancer families with at least one case of male breast cancer, we selected a cohort of 39 such families, tested negative...
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