Article

Hypoxia-induced Response in Mitochondria DNA Biogenesis in Retinal Organoids Derived from Pluripotent Stem Cells from Leber Hereditary Optic Neuropathy

2021-02-16

Abstract excerpt

This study evaluated the impact of hypoxia on mitochondrial DNA (mtDNA) biogenesis in retinal organoids of patients with Leber hereditary optic neuropathy (LHON) with an mtDNA G11778A mutation. The induced pluripotent stem cells derived from the peripheral blood mononuclear cells of LHON patients and a healthy individual were differentiated into three-dimensional retinal organoids with confirmed morphology and ret...

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Literature Corpus work: 42608e47-39fc-549a-9878-6de0a292bb97
DOI: 10.21203/rs.3.rs-197283/v1

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