Article
Gene-gene interaction between PPAR gamma 2 and ADR beta 3 increases obesity risk in children and adolescents.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Nov 2004
Ochoa M C, Marti A, Azcona C, Chueca M, Oyarzábal M, Pelach R, Patiño A, Moreno-Aliaga M J, Martínez-González M A, Martínez J A
Abstract excerpt
AIMS: Multiple genes are likely to be involved in obesity and these genes may interact with environmental factors to influence obesity risk. Our aim was to explore the synergistic contribution of the two polymorphisms: Pro12Ala of the PPAR gamma 2 gene and Trp64Arg of the ADR beta 3 gene to obesity risk in a Spanish children and adolescent population. METHODS: We designed a sex- and age-matched case-control...
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